Resources

We have generated comprehensive genomic datasets across a broad spectrum of pediatric cancers, many of which are accompanied by rich epidemiologic data, including:

• Acute Lymphoblastic Leukemia (ALL)
  • Study design: Case-control
  • 7,366 total cases
  • Summary statistics for ~20,000 case GWAS
• Acute Myeloid Leukemia (AML)
  • Study design: Case-control
  • 1,854 total cases
• Ewing Sarcoma (EWS)
  • Study design: Case-control/case-parent
  • 674 total cases (279 trios, 30 duos)
  • Summary statistics for ~1,800 case GWAS
• Germ Cell Tumors (GCT)
  • Study design: Case-control/case-parent
  • 1,991 total cases (566 trios, 212 duos)
• Hepatoblastoma (HB)
  • Study design: Case-control/case-parent
  • 1064 total cases (193 trios, 96 duos)
• Osteosarcoma (OS)
  • Case-control/case-parent
  • 394 total cases (181 trios, 95 duos)
  • Summary statistics for ~2,500 case GWAS

These locally generated datasets are complemented by aggregated public data from major national and international initiatives, enabling cross‑study discovery and validation:

• Childhood Cancer Data Initiative (CCDI)
• Molecular Characterization Initiative (MCI)
• MP2PRT
• TARGET
• Childhood Cancer Survivor Study (CCSS)
• St. Jude LIFE (SJLIFE)
• Childhood Cancer & Leukemia International Consortium

Together, these resources are externally managed to support discovery across diagnosis, treatment response, toxicity, and survivorship.

Our work is supported by the University’s world-class infrastructure and shared resources:

• Masonic Cancer Center
• Minnesota Supercomputing Institute
• University of Minnesota Genomics Center
• Health Sciences Technology
• Institute for Social Research and Data Innovation